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                             October 12, 2022

       Jeffrey Chi
       Chief Executive Officer
       Vickers Vantage Corp. I
       1 Harbourfront Avenue, #16-06
       Keppel Bay Tower, Singapore 098632
       Singapore

                                                        Re: Vickers Vantage
Corp. I
                                                            Registration
Statement on Form S-4
                                                            Response dated
October 4, 2022
                                                            File No. 333-264941

       Dear Jeffrey Chi:

              We have reviewed your October 4, 2022 response to our comment
letter and have the
       following comments. In some of our comments, we may ask you to provide
us with information
       so we may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.
Unless we note
       otherwise, our references to prior comments are to comments in our
September 23, 2022 letter.

       Registration Statement on Form S-4 filed May 13, 2022

       Questions and Answers About the Business Combination and the Meeting,
page 6

   1.                                                   Please add a Q&A
discussing the material terms of the Funding Letter entered into with
                                                        Sorrento and the
reasoning for entering into this agreement. Please also disclose if any
                                                        consideration was
received by Sorrento in connection with the Funding Letter. In your
                                                        revisions, please
include a discussion of the consequences to investors if the Maximum
                                                        Redemption scenario
occurs and Sorrento elects not to provide funds pursuant to the
                                                        Funding Letter.
 Jeffrey Chi
FirstName   LastNameJeffrey Chi
Vickers Vantage  Corp. I
Comapany
October  12,NameVickers
             2022        Vantage Corp. I
October
Page  2 12, 2022 Page 2
FirstName LastName
Questions and Answers About the Business Combination and the Meeting
Q: What is the Debt Exchange Agreement?, page 7

2.       We note the draft disclosures you intend to include in your next
amendment regarding the
         Funding Letter. Please expand your disclosures to address each of the
following:
             Clarify, if correct, that Sorrento has the option to fund Scilex's
Loan Request under
             the Funding Letter but not the requirement. Discuss the
consequences to the
             Business Combination if Sorrento elects not to provide Scilex with
the loan amount.
             Provide a more recent amount of the Aggregate Outstanding Amount
to the extent
             that additional debt has been incurred by Scilex. In this regard,
we note from your
             draft disclosures on page 310 that Scilex repurchased the
remaining outstanding
             principal balance under the Scilex Pharma Notes of $39.7 million
with only $6.8
             million in cash and cash equivalents as of June 30, 2022.
             Revise the aggregate number of shares of Scilex Preferred Stock
that would be issued
             at closing and the number of shares of New Scilex Series A
Preferred Stock and New
             Scilex Common Stock that would be issued at the Effective Time in
consideration for
             the subsequent debt issuances and the amount Scilex would need to
request under the
             Funding Letter to meet the minimum net tangible asset balance.
         Please address this comment throughout the Form S-4.
Q: What are the possible sources and the extent of dilution that public
shareholders who elect not
to redeem their shares..., page 9

3.       Please update this Q&A to include the potential future sources of
dilution arising from the
         Funding Letter entered into with Sorrento.
Risk Factors, page 39

4.       Please include a risk factor discussing the material risks to
investors arising from the
         funding letter entered into with Sorrento. Please affirmatively state,
if true, that Sorrento
         has the option, but not the obligation, to advance funding to Scilex
to ensure the parties
         meet the net tangible asset requirement of $5,000,001 at the Effective
Time of the
         merger. Your risk factor should also address the material risks to
investors if Sorrento
         does not elect to advance funding to Scilex, including the risk that
the parties may fail to
         meet the net tangible asset requirement and will not be able to
proceed with the business
         combination.
Background of the Business Combination, page 116

5.       Please revise this section to provide a more fulsome description of
the discussions and
         negotiations related to the Funding Letter. Include a discussion of
any negotiated terms,
         parties involved in any negotiations, alternative transactions
considered and the parties'
         reasoning for choosing to enter into the Funding Letter.
 Jeffrey Chi
FirstName   LastNameJeffrey Chi
Vickers Vantage  Corp. I
Comapany
October  12,NameVickers
             2022        Vantage Corp. I
October
Page  3 12, 2022 Page 3
FirstName LastName
Unaudited Pro Forma Condensed Combined Financial Information, page 301

6.       To the extent that Sorrento funded all or any portion of Scilex's
repayment of the Scilex
         Pharma Notes for $39.7 million on September 28, 2022, please revise
the tablular
         presentation at the bottom of page 302 and footnote 4 to update the
Aggregate
         Outstanding Amount per the Debt Exchange Agreement for this
transaction and the
         corresponding number of shares of New Scilex Series A Preferred Stock
and New Scilex
         Common Stock to be issued. To provide investors with a more easily
understandable
         presentation, revise footnote 4 to include a tabular format for the
New Scilex Common
         Stock and New Scilex Series A Preferred Stock to be issued (a) as
merger consideration;
         (b) under the Debt Exchange Agreement based on the Aggregate
Outstanding Amount as
         of June 30, 2022; (c) the additional Aggregate Outstanding Amount due
to the repayment
         of the Scilex Pharma Notes on September 28, 2022; and (d) the
additional Aggregate
         Outstanding Amount due to the Funding Letter under the maximum
redemption scenario
         only.
7.       Based on the language in the draft Funding Letter, it appears that
Sorrento is not required
         to honor any Loan Request by Scilex. If this is correct, please expand
your presentation
         for the maximum redemption scenario to give effect to the full range
of possible results
         (i.e., Sorrento fulfills Scilex's Loan Request and Sorrent elects not
to fulfill Scilex's Loan
         Request). For the scenario under which Sorrento does not elect to
fulfill Scilex's Loan
         Request, clearly disclose the implications to the closing of the
Business Combination.
         Refer to Article 11-02(a)(10) of Regulation S-X for guidance.
8.       Please expand the table presented at the bottom of page 302 to also
disclose the number of
         shares of New Scilex Series A Preferred Stock to be issued to Sorrento
under each
         scenario presented to allow investors to fully understand the capital
structure of the
         merged entity.
Unaudited Pro Forma Condensed Combined Balance Sheet, page 305

9.       Please reflect Scilex's repayment of the Scilex Pharma Notes in
accordance with the
         fourth amendment to those Notes on September 28, 2022. Also address
this comment to
         the corresponding pro forma statements of operations. Refer to Article
11-01(a)(8) of
         Regulation S-X for guidance.
Note 3 - Transaction Adjustments to Unaudited Pro Forma Condensed Combined
Balance Sheet
as of June 30, 2022, page 315

10.      We note the expanded disclosures you intend to include for footnote
(G). It is unclear
         why you have included the expanded disclosures with this footnote,
since the additional
         information is not relevant under the No Redemption Scenario for which
footnote (G)
         relates. Rather, it would appear this additional disclosure is more
appropriately related to
         footnote (O).
11.      We note your addition of footnote (O) for the Funding Letter. Please
expand this
 Jeffrey Chi
Vickers Vantage Corp. I
October 12, 2022
Page 4
      disclosure to demonstrate how the $29.1 million of additional funding
from Sorrento
      results in net tangible assets of $6 million. Ensure your disclosure
clearly addresses the
      $42.6 million of intangibles-net and $13.5 million of goodwill included
in total assets. In
      this regard, we note your reference to Rule 3a51-1(g)(1) of the Exchange
Act on page 7
      for the definition of net tangible assets.
13. Subsequent Events, page F-101

12.   Please expand your disclosures to include the repayment and
extinguishment of the Scilex
      Pharma Notes on September 28, 2022, including how the repayment was
funded and how
      the transaction was accounted for in the financial statements.
       You may contact Tracey Houser at 202-551-3736 or Terence O'Brien at
202-551-3355 if
you have questions regarding comments on the financial statements and related
matters. Please
contact Tyler Howes at 202-551-3370 or Alan Campbell at 202-551-4224 with any
other
questions.



                                                            Sincerely,
FirstName LastNameJeffrey Chi
                                                            Division of
Corporation Finance
Comapany NameVickers Vantage Corp. I
                                                            Office of Life
Sciences
October 12, 2022 Page 4
cc:       Joan Guilfoyle, Esq.
FirstName LastName