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                           August 1, 2022

       Jeffrey Chi
       Chief Executive Officer
       Vickers Vantage Corp. I
       1 Harbourfront Avenue, #16-06
       Keppel Bay Tower, Singapore 098632
       Singapore

                                                        Re: Vickers Vantage
Corp. I
                                                            Amendment No. 2 to
Registration Statement on Form S-4
                                                            Filed July 21, 2022
                                                            File No. 333-264941

       Dear Dr. Chi:

             We have reviewed your amended registration statement and have the
following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.
Unless we note
       otherwise, our references to prior comments are to comments in our July
11, 2022 letter.

       Amendment No. 2 to Registration Statement on Form S-4

       Questions and Answers About the Business Combination and the Meeting,
page 5

   1.                                                   We note your response
to prior comment 2. Please revise this section to include a Q&A
                                                        discussing the material
U.S. federal income tax consequences to Vickers shareholders who
                                                        exercise their
redemption rights.
       Proposal 1 - The Business Combination Proposal
       Background of the Business Combination, page 118

   2.                                                   We note your response
to prior comment 6 and reissue in part. Your disclosure elsewhere
                                                        in the prospectus
indicates that the valuation ascribed to Scilex in the merger is $1.5
 Jeffrey Chi
FirstName   LastNameJeffrey Chi
Vickers Vantage  Corp. I
Comapany
August      NameVickers Vantage Corp. I
        1, 2022
August
Page  2 1, 2022 Page 2
FirstName LastName
         billion less certain Scilex indebtedness. Please revise to provide
more detailed disclosure
         regarding how the parties negotiated and agreed on this valuation. In
your revisions,
         please describe the analysis that Vickers conducted to determine that
the final valuation
         was reasonable. To the extent that the only valuation analysis
conducted by Vickers was
         the review of Scilex's financial projections from Q1 2021 and the
Redwood Projections
         from April 2021 referenced in the disclosure, please so state and
discuss the reasons why
         Vickers' management and board of directors did not conduct additional
valuation review
         or analysis prior to the signing of the Merger Agreement in March
2022. Please also
         quantify Sorrento's January 2021 valuation of Scilex and revise to
disclose the reasons
         Vickers board did not consider this valuation.
Proposal 1 - The Business Combination Proposal
Certain Scilex Projected Financial Information, page 126

3.       We note your disclosure that the Scilex Management Projections were
prepared in the first
         quarter of 2021 while Sorrento did not acquire the rights to SP-104
until April 2021.
         Please further expand your disclosure to explain how you were able to
reasonably estimate
         revenue projections for SP-104 prior to its acquisition. Similarly,
please explain how
         Redwood was also able to estimate the costs of sales using
confidential negotiated
         contract prices with the manufacturer prior to acquisition.
4.       As previously requested in the first bullet to prior comment 8, please
disclose the date
         Redwood prepared the projections and when those projections were
received by Scilex
         management. Further, explain why the Vickers Board received the
Redwood projections
         in April 2021 when the non-disclosure agreement was not entered into
until June 9, 2021.
5.       Please expand your disclosures for footnote 4 to the Scilex Management
Projections, to
         clarify that the assumption SP-102 would receive regulatory approval
in the first half of
         2022 with commercialization in the second half of 2022 was not met.
Similarly, please
         clarify whether the expectations for the receipt of regulatory
approval and
         commercialization for SP-103 and SP-104 remain consistent with the
expectations used in
         preparing the projections.
6.       For the Redwood Projections, please expand footnotes 4 and 5 to
address those years that
         do not appear to be consistent with the disclosure in terms of how the
amount was
         estimated. In this regard, we note that operating expenses for fiscal
year 2023 only
         increased 1.7%, fiscal years 2025 and 2028 declined. Similarly, total
other income
         & expense for fiscal years 2027 through 2030 increase well over the
4-5% disclosed
         increase.
Index to Financial Statements
15. Subsequent Events
Sorrento Cash Contribution, page F-79

7.       Please revise your disclosure to appropriately characterize this
transaction and to provide
 Jeffrey Chi
Vickers Vantage Corp. I
August 1, 2022
Page 3
      context for the transaction. Refer to your response to prior comment 15
in your letter
      dated July 20, 2022 and to the FASB Codification   s Master Glossary for
the definition of
      contribution.
General

8.    We note your response to prior comment 16. We also note disclosure on
page 196 and 288
      stating Scilex relied upon input from its financial advisors regarding
trends for similar
      transactions in determining the interim redemption scenario. Please
reconcile your
      disclosure or advise.
9.    With a view toward disclosure, please tell us whether your sponsor is, is
controlled by, or
      has substantial ties with a non-U.S. person. If so, also include risk
factor disclosure that
      addresses how this fact could impact your ability to complete your
initial business
      combination. For instance, discuss the risk to investors that you may not
be able to
      complete an initial business combination with a U.S. target company
should the
      transaction be subject to review by a U.S. government entity, such as the
Committee on
      Foreign Investment in the United States (CFIUS), or ultimately
prohibited. Disclose that
      as a result, the pool of potential targets with which you could complete
an initial business
      combination may be limited. Further, disclose that the time necessary for
government
      review of the transaction or a decision to prohibit the transaction could
prevent you from
      completing an initial business combination and require you to liquidate.
Disclose the
      consequences of liquidation to investors, such as the losses of the
investment opportunity
      in a target company, any price appreciation in the combined company, and
the warrants,
      which would expire worthless.
       You may contact Tracey Houser at 202-551-3736 or Terence O'Brien at
202-551-3355 if
you have questions regarding comments on the financial statements and related
matters. Please
contact Tyler Howes at 202-551-3370 or Alan Campbell at 202-551-4224 with any
other
questions.



                                                            Sincerely,
FirstName LastNameJeffrey Chi
                                                            Division of
Corporation Finance
Comapany NameVickers Vantage Corp. I
                                                            Office of Life
Sciences
August 1, 2022 Page 3
cc:       Joan Guilfoyle, Esq.
FirstName LastName