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<link:definition>1013 - Disclosure - Debt</link:definition>
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<link:definition>1014 - Disclosure - Junior DIP Facility and Sorrento Share Purchase Agreement</link:definition>
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<link:definition>1018 - Disclosure - Income Taxes</link:definition>
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<link:definition>1019 - Disclosure - Net Loss Per Share</link:definition>
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<link:definition>1021 - Disclosure - Nature of Operations and Basis of Presentation (Policies)</link:definition>
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<link:definition>1022 - Disclosure - Nature of Operations and Basis of Presentation (Tables)</link:definition>
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<link:definition>1023 - Disclosure - Fair Value Measurements (Tables)</link:definition>
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<link:definition>1024 - Disclosure - Balance Sheet Components (Tables)</link:definition>
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<link:definition>1025 - Disclosure - Goodwill and Intangible Assets (Tables)</link:definition>
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<link:definition>1026 - Disclosure - Debt (Tables)</link:definition>
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<link:definition>1027 - Disclosure - Stock Incentive and Employee Benefit Plans (Tables)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1028 - Disclosure - Commitments and Contingencies (Tables)</link:definition>
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<link:definition>1029 - Disclosure - Income Taxes (Tables)</link:definition>
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<link:definition>1030 - Disclosure - Net Loss Per Share (Tables)</link:definition>
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<link:definition>1031 - Disclosure - Nature of Operations and Basis of Presentation (Additional Information) (Details)</link:definition>
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<link:definition>1032 - Disclosure - Nature of Operations and Basis of Presentation - Schedule of Cash and Cash Equivalents (Details)</link:definition>
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<link:definition>1035 - Disclosure - Fair Value Measurements (Additional Information) (Details)</link:definition>
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<link:definition>1036 - Disclosure - Fair Value Measurements  (Details) - Schedule of fair value assets measured on a recurring basis</link:definition>
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<link:definition>1038 - Disclosure - Fair Value Measurements (Details) - Schedule of The Inputs Used In Valuing The Derivative Warrant Liabilities</link:definition>
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<link:definition>1039 - Disclosure - Balance Sheet Components - Schedule of Property and Equipment (Details)</link:definition>
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<link:definition>1040 - Disclosure - Balance Sheet Components - Schedule of Acrcued expenses - Details (Details)</link:definition>
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<link:definition>1041 - Disclosure - Balance Sheet Components (Additional Information) (Details)</link:definition>
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<link:definition>1042 - Disclosure - Goodwill and Intangible Assets (Additional Information) (Details)</link:definition>
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<link:definition>1043 - Disclosure - Goodwill and Intangible Assets - Summary of identifiable intangible assets (Details)</link:definition>
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<link:definition>1044 - Disclosure - Goodwill and Intangible Assets - Estimated future amortization expense of intangible assets (Details)</link:definition>
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<link:definition>1045 - Disclosure - Debt (Additional Information) (Details)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1046 - Disclosure - Debt - Summery of Outstanding Convertible Debenture (Details)</link:definition>
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<link:definition>1047 - Disclosure - Debt - Schedule of FSF Deposit (Details)</link:definition>
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<link:definition>1048 - Disclosure - Debt - Schedule of Tranche B Notes (Details)</link:definition>
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<link:definition>1049 - Disclosure - Debt - Schedule of revenue liability activity (Details)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1050 - Disclosure - Junior DIP Facility and Sorrento Share Purchase Agreement (Additional Information) (Details)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1051 - Disclosure - Shareholders' Deficit (Additional Information) (Details)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1052 - Disclosure - Stock Incentive and Employee Benefit Plans - Schedule of Stock Options Outstanding Activity (Details)</link:definition>
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<link:definition>1053 - Disclosure - Stock Incentive and Employee Benefit Plans - Schedule of estimate stock-based compensation on the date of grant for stock options and ESPP (Details)</link:definition>
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<link:definition>1054 - Disclosure - Stock Incentive and Employee Benefit Plans (Additional Information) (Details)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1055 - Disclosure - Commitments and Contingencies - Schedule of Leases Supplemental Quantitative Information (Details)</link:definition>
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<element name="ScilexPharmaMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_ScilexPharmaMember" substitutionGroup="xbrli:item" />
<element name="TrancheBNoteMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_TrancheBNoteMember" substitutionGroup="xbrli:item" />
<element name="RoyaltyPurchaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_RoyaltyPurchaseAgreementMember" substitutionGroup="xbrli:item" />
<element name="FristInstallmentMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_FristInstallmentMember" substitutionGroup="xbrli:item" />
<element name="SecondInstallmentMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_SecondInstallmentMember" substitutionGroup="xbrli:item" />
<element name="ThirdInstallmentMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_ThirdInstallmentMember" substitutionGroup="xbrli:item" />
<element name="FourthInstallmentMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_FourthInstallmentMember" substitutionGroup="xbrli:item" />
<element name="FiveInstallmentMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_FiveInstallmentMember" substitutionGroup="xbrli:item" />
<element name="SixInstallmentMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_SixInstallmentMember" substitutionGroup="xbrli:item" />
<element name="OctoberCommonWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_OctoberCommonWarrantsMember" substitutionGroup="xbrli:item" />
<element name="DebtPayableAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_DebtPayableAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="DebtPayableDomain" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_DebtPayableDomain" substitutionGroup="xbrli:item" />
<element name="MonthlyBasisMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_MonthlyBasisMember" substitutionGroup="xbrli:item" />
<element name="LoanAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_LoanAmount" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DepositWarrantExercisePrice" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_DepositWarrantExercisePrice" substitutionGroup="xbrli:item" />
<element name="CommitmentAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_CommitmentAmount" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="CompanyReceivesTheFsfDepositAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_CompanyReceivesTheFsfDepositAmount" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="CompanyReceivesTheFsfDepositPeriod" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_CompanyReceivesTheFsfDepositPeriod" substitutionGroup="xbrli:item" />
<element name="ProceedsReceivedFromPurchaseAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_ProceedsReceivedFromPurchaseAgreement" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="NetCashProceeds" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_NetCashProceeds" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="TerminationFees" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_TerminationFees" substitutionGroup="xbrli:item" />
<element name="PurchaseOfCommonWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_PurchaseOfCommonWarrants" substitutionGroup="xbrli:item" />
<element name="DebtRepaymentExitFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_DebtRepaymentExitFee" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ExistingFacilityCapMaximum" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_ExistingFacilityCapMaximum" substitutionGroup="xbrli:item" />
<element name="ExistingFacilityCapMinimum" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_ExistingFacilityCapMinimum" substitutionGroup="xbrli:item" />
<element name="DebtInstrumentOutstandingPrincipal" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_DebtInstrumentOutstandingPrincipal" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="DebtInstrumentPrincipalAmountPercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_DebtInstrumentPrincipalAmountPercentage" substitutionGroup="xbrli:item" />
<element name="ConvertibleDebenturesIssuedPercent" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_ConvertibleDebenturesIssuedPercent" substitutionGroup="xbrli:item" />
<element name="DebtInstrumentOwnedPercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_DebtInstrumentOwnedPercentage" substitutionGroup="xbrli:item" />
<element name="DebtInstrumentDefaultInterestRate" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_DebtInstrumentDefaultInterestRate" substitutionGroup="xbrli:item" />
<element name="DebtInstrumentPercentageOfInterestAccruedOnPrincipalAmount" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_DebtInstrumentPercentageOfInterestAccruedOnPrincipalAmount" substitutionGroup="xbrli:item" />
<element name="DebtRepaymentPercentageOfMandatoryDefaultRateOfPrincipalAmount" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_DebtRepaymentPercentageOfMandatoryDefaultRateOfPrincipalAmount" substitutionGroup="xbrli:item" />
<element name="DebtRepaymentPercentageOfMandatoryDefaultRateOfAccruedAndUnpaidInterest" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_DebtRepaymentPercentageOfMandatoryDefaultRateOfAccruedAndUnpaidInterest" substitutionGroup="xbrli:item" />
<element name="PercentageOfUsageOfCashProceedsFromCashSweepFinancing" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_PercentageOfUsageOfCashProceedsFromCashSweepFinancing" substitutionGroup="xbrli:item" />
<element name="PaidToRoyaltyInvestors" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_PaidToRoyaltyInvestors" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="RepaymentOfConvertibleDebenture" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_RepaymentOfConvertibleDebenture" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ChangeInFairValueOfConvertibleDebentures" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_ChangeInFairValueOfConvertibleDebentures" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="FSFLoanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_FSFLoanMember" substitutionGroup="xbrli:item" />
<element name="RepaymentOfDeposit" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_RepaymentOfDeposit" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="RepaymentOfTrancheBNotes" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_RepaymentOfTrancheBNotes" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ChangeInFairValueOfTrancheBNotes" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_ChangeInFairValueOfTrancheBNotes" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ChangeInFairValueOfPurchasedRevenueLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_ChangeInFairValueOfPurchasedRevenueLiability" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="JuniorDipFacilityMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_JuniorDipFacilityMember" substitutionGroup="xbrli:item" />
<element name="StockPurchaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_StockPurchaseAgreementMember" substitutionGroup="xbrli:item" />
<element name="ClosingPennyWarrantMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_ClosingPennyWarrantMember" substitutionGroup="xbrli:item" />
<element name="SubsequentPennyWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_SubsequentPennyWarrantsMember" substitutionGroup="xbrli:item" />
<element name="PennyWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_PennyWarrantsMember" substitutionGroup="xbrli:item" />
<element name="SubsequentPennyWarrants2Member" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_SubsequentPennyWarrants2Member" substitutionGroup="xbrli:item" />
<element name="SubsequentPennyWarrants3Member" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_SubsequentPennyWarrants3Member" substitutionGroup="xbrli:item" />
<element name="SubsequentPennyWarrants4Member" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_SubsequentPennyWarrants4Member" substitutionGroup="xbrli:item" />
<element name="SubsequentPennyWarrants5Member" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_SubsequentPennyWarrants5Member" substitutionGroup="xbrli:item" />
<element name="PrivateWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_PrivateWarrantsMember" substitutionGroup="xbrli:item" />
<element name="PublicWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_PublicWarrantsMember" substitutionGroup="xbrli:item" />
<element name="IssueOfWarrantsToPurchaseShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_IssueOfWarrantsToPurchaseShares" substitutionGroup="xbrli:item" />
<element name="NumberOfShareOutstanding" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_NumberOfShareOutstanding" substitutionGroup="xbrli:item" />
<element name="TransferOfWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_TransferOfWarrants" substitutionGroup="xbrli:item" />
<element name="CashPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_CashPayment" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="FairValueOfSharesRepurchased" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_FairValueOfSharesRepurchased" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="FairValueOfWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_FairValueOfWarrants" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="WarrantVestingDate" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_WarrantVestingDate" substitutionGroup="xbrli:item" />
<element name="PennyWarrantsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_PennyWarrantsExercised" substitutionGroup="xbrli:item" />
<element name="ShareholdersEquityDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_ShareholdersEquityDetailsTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="SpacWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_SpacWarrantsMember" substitutionGroup="xbrli:item" />
<element name="CommonWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_CommonWarrantsMember" substitutionGroup="xbrli:item" />
<element name="PlacementAgentWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_PlacementAgentWarrantsMember" substitutionGroup="xbrli:item" />
<element name="PublicWarrantsPurchaseCommonStockMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_PublicWarrantsPurchaseCommonStockMember" substitutionGroup="xbrli:item" />
<element name="RepresentativeWarrantsOutstandingMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_RepresentativeWarrantsOutstandingMember" substitutionGroup="xbrli:item" />
<element name="FirmWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_FirmWarrantsMember" substitutionGroup="xbrli:item" />
<element name="RegisteredDirectOfferingMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_RegisteredDirectOfferingMember" substitutionGroup="xbrli:item" />
<element name="WarrantTransferAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_WarrantTransferAgreementMember" substitutionGroup="xbrli:item" />
<element name="BRileyPurchaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_BRileyPurchaseAgreementMember" substitutionGroup="xbrli:item" />
<element name="AtTheMarketSalesAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_AtTheMarketSalesAgreementMember" substitutionGroup="xbrli:item" />
<element name="HudsonBayMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_HudsonBayMember" substitutionGroup="xbrli:item" />
<element name="CoveLaneMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_CoveLaneMember" substitutionGroup="xbrli:item" />
<element name="ShareholdersEquityDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_ShareholdersEquityDetailsLineItems" substitutionGroup="xbrli:item" />
<element name="PurchaseOfStockPercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_PurchaseOfStockPercentage" substitutionGroup="xbrli:item" />
<element name="CommonStockSold" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_CommonStockSold" substitutionGroup="xbrli:item" />
<element name="ProceedSOfSaleOfCommonSharesPercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_ProceedSOfSaleOfCommonSharesPercentage" substitutionGroup="xbrli:item" />
<element name="CombinedPricePaidOfWarrant" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_CombinedPricePaidOfWarrant" substitutionGroup="xbrli:item" />
<element name="PublicOfferingPrice" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_PublicOfferingPrice" substitutionGroup="xbrli:item" />
<element name="ExercisePriceOfCommonWarrant" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_ExercisePriceOfCommonWarrant" substitutionGroup="xbrli:item" />
<element name="PublicOfferingPriceCombined" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_PublicOfferingPriceCombined" substitutionGroup="xbrli:item" />
<element name="PreFundedWarrantsToPurchase" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_PreFundedWarrantsToPurchase" substitutionGroup="xbrli:item" />
<element name="PreFundedWarrantPerShare" type="dtr-types:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_PreFundedWarrantPerShare" substitutionGroup="xbrli:item" />
<element name="CashFeePercentageOfGrossProceedsPaidToPlacementAgents" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_CashFeePercentageOfGrossProceedsPaidToPlacementAgents" substitutionGroup="xbrli:item" />
<element name="ClearingExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_ClearingExpenses" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="PercentOfTotalNumberOfSharesIssuedToAgentsInTheOffering" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_PercentOfTotalNumberOfSharesIssuedToAgentsInTheOffering" substitutionGroup="xbrli:item" />
<element name="PercentOfCombinedOfferingExercisePricePerShare" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_PercentOfCombinedOfferingExercisePricePerShare" substitutionGroup="xbrli:item" />
<element name="AggregateGrossProceedsFromOffering" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_AggregateGrossProceedsFromOffering" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="NumberOfWarrantsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_NumberOfWarrantsExercised" substitutionGroup="xbrli:item" />
<element name="BlackScholesOptionPricingMethodMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_BlackScholesOptionPricingMethodMember" substitutionGroup="xbrli:item" />
<element name="EmployeeStockPurchasePlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_EmployeeStockPurchasePlanMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandTwentyTwoEquityIncentivePlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_TwoThousandTwentyTwoEquityIncentivePlanMember" substitutionGroup="xbrli:item" />
<element name="Semnur2024StockOptionPlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_Semnur2024StockOptionPlanMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandTwentyThreeInducementPlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_TwoThousandTwentyThreeInducementPlanMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandTwentyTwoEmployeeStockPurchasePlanMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_TwoThousandTwentyTwoEmployeeStockPurchasePlanMember" substitutionGroup="xbrli:item" />
<element name="WeightedAveragePeriodOverGrant" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_WeightedAveragePeriodOverGrant" substitutionGroup="xbrli:item" />
<element name="LeaseLiabilityNetOfCurrentPortion" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_LeaseLiabilityNetOfCurrentPortion" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="CommitmentsAndContingenciesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_CommitmentsAndContingenciesTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="ProductDevelopmentAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_ProductDevelopmentAgreementMember" substitutionGroup="xbrli:item" />
<element name="NonCancelableLeaseAgreementsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_NonCancelableLeaseAgreementsMember" substitutionGroup="xbrli:item" />
<element name="EpoladermMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_EpoladermMember" substitutionGroup="xbrli:item" />
<element name="ProbudurMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_ProbudurMember" substitutionGroup="xbrli:item" />
<element name="EnveltaMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_EnveltaMember" substitutionGroup="xbrli:item" />
<element name="DevelopersMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_DevelopersMember" substitutionGroup="xbrli:item" />
<element name="GloperbaMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_GloperbaMember" substitutionGroup="xbrli:item" />
<element name="FormerEmployeeMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_FormerEmployeeMember" substitutionGroup="xbrli:item" />
<element name="FormerEmployeeOneMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_FormerEmployeeOneMember" substitutionGroup="xbrli:item" />
<element name="ResearchAndDevelopmentFacilitiesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_ResearchAndDevelopmentFacilitiesMember" substitutionGroup="xbrli:item" />
<element name="CommitmentsAndContingenciesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_CommitmentsAndContingenciesLineItems" substitutionGroup="xbrli:item" />
<element name="RoyaltyPaymentPercentageRelatedToFutureYears" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_RoyaltyPaymentPercentageRelatedToFutureYears" substitutionGroup="xbrli:item" />
<element name="RoyaltyPaymentPercentageOnNetSale" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_RoyaltyPaymentPercentageOnNetSale" substitutionGroup="xbrli:item" />
<element name="AgreementMaturityDate" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_AgreementMaturityDate" substitutionGroup="xbrli:item" />
<element name="MaturityRenewalDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_MaturityRenewalDescription" substitutionGroup="xbrli:item" />
<element name="DueFromRelatedParty" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_DueFromRelatedParty" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="DeferredTaxAssetsDebtRelatedInterest" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_DeferredTaxAssetsDebtRelatedInterest" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DeferredTaxAssetsAccruedExpenseAndReserves" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_DeferredTaxAssetsAccruedExpenseAndReserves" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DeferredTaxAssetsPurchasedRevenueLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_DeferredTaxAssetsPurchasedRevenueLiability" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DeferredTaxAssetsOperatingLeaseLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_DeferredTaxAssetsOperatingLeaseLiabilities" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="IncomeTaxReconciliationValuationAllowanceAtFederalStatutoryIncomeTaxRate" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_IncomeTaxReconciliationValuationAllowanceAtFederalStatutoryIncomeTaxRate" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="IncomeTaxReconciliationAcquisitionRelatedCharges" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_IncomeTaxReconciliationAcquisitionRelatedCharges" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="EffectiveIncomeTaxRateReconciliationChangeInFairValueOfConvertibleDebenturesAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_EffectiveIncomeTaxRateReconciliationChangeInFairValueOfConvertibleDebenturesAmount" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="EffectiveIncomeTaxRateReconciliationChangeInTaxRatesAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_EffectiveIncomeTaxRateReconciliationChangeInTaxRatesAmount" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="IncomeTaxDisclosureLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_IncomeTaxDisclosureLineItems" substitutionGroup="xbrli:item" />
<element name="IndefiniteOperatingLossCarryforwards" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_IndefiniteOperatingLossCarryforwards" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="OperatingLossCarryforwardsExpirationYear" type="xbrli:gYearItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_OperatingLossCarryforwardsExpirationYear" substitutionGroup="xbrli:item" />
<element name="TaxCreditCarryforwardNotSubjectToExpireAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_TaxCreditCarryforwardNotSubjectToExpireAmount" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="IncomeTaxCreditsExpirationYear" type="xbrli:gYearItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_IncomeTaxCreditsExpirationYear" substitutionGroup="xbrli:item" />
<element name="WeightedAverageNumberOfSharesOutstanding" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_WeightedAverageNumberOfSharesOutstanding" substitutionGroup="xbrli:item" />
<element name="WeightedAverageCommonStockWarrantsExercisableNominalConsideration" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_WeightedAverageCommonStockWarrantsExercisableNominalConsideration" substitutionGroup="xbrli:item" />
<element name="EffectOfDilutiveSecurities" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_EffectOfDilutiveSecurities" substitutionGroup="xbrli:item" />
<element name="StockOptionsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_StockOptionsMember" substitutionGroup="xbrli:item" />
<element name="February2024BDOFirmWarrantMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_February2024BDOFirmWarrantMember" substitutionGroup="xbrli:item" />
<element name="April2024RDOPlacementAgentWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_April2024RDOPlacementAgentWarrantsMember" substitutionGroup="xbrli:item" />
<element name="RetainerSharesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_RetainerSharesMember" substitutionGroup="xbrli:item" />
<element name="February2024BDORepresentativeWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_February2024BDORepresentativeWarrantsMember" substitutionGroup="xbrli:item" />
<element name="SharesIssuablePursuantToEsppMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_SharesIssuablePursuantToEsppMember" substitutionGroup="xbrli:item" />
<element name="SharesIssuableUnderSponsorInterestPurchaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_SharesIssuableUnderSponsorInterestPurchaseAgreementMember" substitutionGroup="xbrli:item" />
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<element name="October2024PlacementAgentWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_October2024PlacementAgentWarrantsMember" substitutionGroup="xbrli:item" />
<element name="StockBlockWarrantsMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_StockBlockWarrantsMember" substitutionGroup="xbrli:item" />
<element name="SharesIssuableUnderTrancheBNotesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_SharesIssuableUnderTrancheBNotesMember" substitutionGroup="xbrli:item" />
<element name="DeferralAndConsentUnderTrancheBSeniorSecuredConvertibleNoteMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_DeferralAndConsentUnderTrancheBSeniorSecuredConvertibleNoteMember" substitutionGroup="xbrli:item" />
<element name="ZTlidoRestOfWorldLicenseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_ZTlidoRestOfWorldLicenseAgreementMember" substitutionGroup="xbrli:item" />
<element name="Gloperba-ElyxybRoyaltyPurchaseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_Gloperba-ElyxybRoyaltyPurchaseAgreementMember" substitutionGroup="xbrli:item" />
<element name="GloperbaRestOfWorldLicenseAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_GloperbaRestOfWorldLicenseAgreementMember" substitutionGroup="xbrli:item" />
<element name="ThreeILpMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_ThreeILpMember" substitutionGroup="xbrli:item" />
<element name="BpyLimitedMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_BpyLimitedMember" substitutionGroup="xbrli:item" />
<element name="NomisBayLtdMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="sclx_NomisBayLtdMember" substitutionGroup="xbrli:item" />
<element name="TotalNumberOfSharesGranted" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_TotalNumberOfSharesGranted" substitutionGroup="xbrli:item" />
<element name="RoyaltyAgreementDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_RoyaltyAgreementDescription" substitutionGroup="xbrli:item" />
<element name="RoyaltyRatePercentage" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_RoyaltyRatePercentage" substitutionGroup="xbrli:item" />
<element name="PercentageOfLidocaineTopicalSystem" type="dtr-types:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_PercentageOfLidocaineTopicalSystem" substitutionGroup="xbrli:item" />
<element name="NoOfCalendarDays" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="sclx_NoOfCalendarDays" substitutionGroup="xbrli:item" />
<element name="SharesDelivered" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_SharesDelivered" substitutionGroup="xbrli:item" />
<element name="AggregatePaymentOfCompany" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="sclx_AggregatePaymentOfCompany" substitutionGroup="xbrli:item" xbrli:balance="debit" />
</schema>
